Amplitude targets the development of new multimodal imaging systems exploiting novel laser sources and state-of-the-art imaging and spectroscopic technologies to fulfil unmet clinical needs in terms of the specificity and accuracy of cancer diagnosis and therapy monitoring.

Amplitude aims to develop a system that exploits the optical properties of near-infrared (NIR), instead of visible or UV light, to image deep inside tissues. Using novel ultrafast light sources, the project will investigate a new concept of label-free, multi-modal microscopy and endoscopic imaging based on an under explored wavelength region between 1650nm and 1870nm (the 3rd biological window). Using this wavelength range Amplitude will develop high resolution imaging and spectroscopic technologies, including NIR confocal reflectance microscopy, multi-photon microscopy and spontaneous Raman spectroscopy to enable exhaustive characterisation of the morphological, metabolic and molecular characteristics of tissues.